| W1 | SEP 7, 2025 |  Cincinnati BengalsCincinnati Bengals @ Cleveland Browns | Home | 17 - 16 | Final | Open |
| W2 | SEP 14, 2025 |  Baltimore RavensCleveland Browns @ Baltimore Ravens | Away | 17 - 41 | Final | Open |
| W3 | SEP 21, 2025 |  Green Bay PackersGreen Bay Packers @ Cleveland Browns | Home | 10 - 13 | Final | Open |
| W4 | SEP 28, 2025 |  Detroit LionsCleveland Browns @ Detroit Lions | Away | 10 - 34 | Final | Open |
| W5 | OCT 5, 2025 |  Minnesota VikingsMinnesota Vikings @ Cleveland Browns | Home | 21 - 17 | Final | Open |
| W6 | OCT 12, 2025 |  Pittsburgh SteelersCleveland Browns @ Pittsburgh Steelers | Away | 9 - 23 | Final | Open |
| W7 | OCT 19, 2025 |  Miami DolphinsMiami Dolphins @ Cleveland Browns | Home | 6 - 31 | Final | Open |
| W8 | OCT 26, 2025 |  New England PatriotsCleveland Browns @ New England Patriots | Away | 13 - 32 | Final | Open |
| W9 | - | ByeCleveland Browns Bye Week | - | - | Bye | Rest |
| W10 | NOV 9, 2025 |  New York JetsCleveland Browns @ New York Jets | Away | 20 - 27 | Final | Open |
| W11 | NOV 16, 2025 | Baltimore RavensBaltimore Ravens @ Cleveland Browns | Home | 23 - 16 | Final | Open |
| W12 | NOV 23, 2025 |  Las Vegas RaidersCleveland Browns @ Las Vegas Raiders | Away | 24 - 10 | Final | Open |
| W13 | NOV 30, 2025 |  San Francisco 49ersSan Francisco 49ers @ Cleveland Browns | Home | 26 - 8 | Final | Open |
| W14 | DEC 7, 2025 |  Tennessee TitansTennessee Titans @ Cleveland Browns | Home | 31 - 29 | Final | Open |
| W15 | DEC 14, 2025 |  Chicago BearsCleveland Browns @ Chicago Bears | Away | 3 - 31 | Final | Open |
| W16 | DEC 21, 2025 |  Buffalo BillsBuffalo Bills @ Cleveland Browns | Home | 23 - 20 | Final | Open |
| W17 | DEC 28, 2025 | Pittsburgh SteelersPittsburgh Steelers @ Cleveland Browns | Home | 6 - 13 | Final | Open |
| W18 | JAN 4, 2026 | Cincinnati BengalsCleveland Browns @ Cincinnati Bengals | Away | 20 - 18 | Final | Open |
