| W1 | SEP 8, 2025 |  Minnesota VikingsMinnesota Vikings @ Chicago Bears | Home | 27 - 24 | Final | Open |
| W2 | SEP 14, 2025 |  Detroit LionsChicago Bears @ Detroit Lions | Away | 21 - 52 | Final | Open |
| W3 | SEP 21, 2025 |  Dallas CowboysDallas Cowboys @ Chicago Bears | Home | 14 - 31 | Final | Open |
| W4 | SEP 28, 2025 |  Las Vegas RaidersChicago Bears @ Las Vegas Raiders | Away | 25 - 24 | Final | Open |
| W5 | - | ByeChicago Bears Bye Week | - | - | Bye | Rest |
| W6 | OCT 13, 2025 |  Washington CommandersChicago Bears @ Washington Commanders | Away | 25 - 24 | Final | Open |
| W7 | OCT 19, 2025 |  New Orleans SaintsNew Orleans Saints @ Chicago Bears | Home | 14 - 26 | Final | Open |
| W8 | OCT 26, 2025 |  Baltimore RavensChicago Bears @ Baltimore Ravens | Away | 16 - 30 | Final | Open |
| W9 | NOV 2, 2025 |  Cincinnati BengalsChicago Bears @ Cincinnati Bengals | Away | 47 - 42 | Final | Open |
| W10 | NOV 9, 2025 |  New York GiantsNew York Giants @ Chicago Bears | Home | 20 - 24 | Final | Open |
| W11 | NOV 16, 2025 | Minnesota VikingsChicago Bears @ Minnesota Vikings | Away | 19 - 17 | Final | Open |
| W12 | NOV 23, 2025 |  Pittsburgh SteelersPittsburgh Steelers @ Chicago Bears | Home | 28 - 31 | Final | Open |
| W13 | NOV 28, 2025 |  Philadelphia EaglesChicago Bears @ Philadelphia Eagles | Away | 24 - 15 | Final | Open |
| W14 | DEC 7, 2025 |  Green Bay PackersChicago Bears @ Green Bay Packers | Away | 21 - 28 | Final | Open |
| W15 | DEC 14, 2025 |  Cleveland BrownsCleveland Browns @ Chicago Bears | Home | 3 - 31 | Final | Open |
| W16 | DEC 20, 2025 | Green Bay PackersGreen Bay Packers @ Chicago Bears | Home | 16 - 22 | Final | Open |
| W17 | DEC 28, 2025 |  San Francisco 49ersChicago Bears @ San Francisco 49ers | Away | 38 - 42 | Final | Open |
| W18 | JAN 4, 2026 | Detroit LionsDetroit Lions @ Chicago Bears | Home | 19 - 16 | Final | Open |
