| W1 | SEP 7, 2025 |  Jacksonville JaguarsCarolina Panthers @ Jacksonville Jaguars | Away | 10 - 26 | Final | Open |
| W2 | SEP 14, 2025 |  Arizona CardinalsCarolina Panthers @ Arizona Cardinals | Away | 22 - 27 | Final | Open |
| W3 | SEP 21, 2025 |  Atlanta FalconsAtlanta Falcons @ Carolina Panthers | Home | 0 - 30 | Final | Open |
| W4 | SEP 28, 2025 |  New England PatriotsCarolina Panthers @ New England Patriots | Away | 13 - 42 | Final | Open |
| W5 | OCT 5, 2025 |  Miami DolphinsMiami Dolphins @ Carolina Panthers | Home | 24 - 27 | Final | Open |
| W6 | OCT 12, 2025 |  Dallas CowboysDallas Cowboys @ Carolina Panthers | Home | 27 - 30 | Final | Open |
| W7 | OCT 19, 2025 |  New York JetsCarolina Panthers @ New York Jets | Away | 13 - 6 | Final | Open |
| W8 | OCT 26, 2025 |  Buffalo BillsBuffalo Bills @ Carolina Panthers | Home | 40 - 9 | Final | Open |
| W9 | NOV 2, 2025 |  Green Bay PackersCarolina Panthers @ Green Bay Packers | Away | 16 - 13 | Final | Open |
| W10 | NOV 9, 2025 |  New Orleans SaintsNew Orleans Saints @ Carolina Panthers | Home | 17 - 7 | Final | Open |
| W11 | NOV 16, 2025 | Atlanta FalconsCarolina Panthers @ Atlanta Falcons | Away | 30 - 27 | Final | Open |
| W12 | NOV 24, 2025 |  San Francisco 49ersCarolina Panthers @ San Francisco 49ers | Away | 9 - 20 | Final | Open |
| W13 | NOV 30, 2025 |  Los Angeles RamsLos Angeles Rams @ Carolina Panthers | Home | 28 - 31 | Final | Open |
| W14 | - | ByeCarolina Panthers Bye Week | - | - | Bye | Rest |
| W15 | DEC 14, 2025 | New Orleans SaintsCarolina Panthers @ New Orleans Saints | Away | 17 - 20 | Final | Open |
| W16 | DEC 21, 2025 |  Tampa Bay BuccaneersTampa Bay Buccaneers @ Carolina Panthers | Home | 20 - 23 | Final | Open |
| W17 | DEC 28, 2025 |  Seattle SeahawksSeattle Seahawks @ Carolina Panthers | Home | 27 - 10 | Final | Open |
| W18 | JAN 3, 2026 | Tampa Bay BuccaneersCarolina Panthers @ Tampa Bay Buccaneers | Away | 14 - 16 | Final | Open |
