| W1 | SEP 7, 2025 |  New York GiantsNew York Giants @ Washington Commanders | Home | 6 - 21 | Final | Open |
| W2 | SEP 11, 2025 |  Green Bay PackersWashington Commanders @ Green Bay Packers | Away | 18 - 27 | Final | Open |
| W3 | SEP 21, 2025 |  Las Vegas RaidersLas Vegas Raiders @ Washington Commanders | Home | 24 - 41 | Final | Open |
| W4 | SEP 28, 2025 |  Atlanta FalconsWashington Commanders @ Atlanta Falcons | Away | 27 - 34 | Final | Open |
| W5 | OCT 5, 2025 |  Los Angeles ChargersWashington Commanders @ Los Angeles Chargers | Away | 27 - 10 | Final | Open |
| W6 | OCT 13, 2025 |  Chicago BearsChicago Bears @ Washington Commanders | Home | 25 - 24 | Final | Open |
| W7 | OCT 19, 2025 |  Dallas CowboysWashington Commanders @ Dallas Cowboys | Away | 22 - 44 | Final | Open |
| W8 | OCT 27, 2025 |  Kansas City ChiefsWashington Commanders @ Kansas City Chiefs | Away | 7 - 28 | Final | Open |
| W9 | NOV 2, 2025 |  Seattle SeahawksSeattle Seahawks @ Washington Commanders | Home | 38 - 14 | Final | Open |
| W10 | NOV 9, 2025 |  Detroit LionsDetroit Lions @ Washington Commanders | Home | 44 - 22 | Final | Open |
| W11 | NOV 16, 2025 |  Miami DolphinsWashington Commanders @ Miami Dolphins | Away | 13 - 16 | Final | Open |
| W12 | - | ByeWashington Commanders Bye Week | - | - | Bye | Rest |
| W13 | NOV 30, 2025 |  Denver BroncosDenver Broncos @ Washington Commanders | Home | 27 - 26 | Final | Open |
| W14 | DEC 7, 2025 |  Minnesota VikingsWashington Commanders @ Minnesota Vikings | Away | 0 - 31 | Final | Open |
| W15 | DEC 14, 2025 | New York GiantsWashington Commanders @ New York Giants | Away | 29 - 21 | Final | Open |
| W16 | DEC 20, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Washington Commanders | Home | 29 - 18 | Final | Open |
| W17 | DEC 25, 2025 | Dallas CowboysDallas Cowboys @ Washington Commanders | Home | 30 - 23 | Final | Open |
| W18 | JAN 4, 2026 | Philadelphia EaglesWashington Commanders @ Philadelphia Eagles | Away | 24 - 17 | Final | Open |
