| W1 | SEP 7, 2025 |  Denver BroncosTennessee Titans @ Denver Broncos | Away | 12 - 20 | Final | Open |
| W2 | SEP 14, 2025 |  Los Angeles RamsLos Angeles Rams @ Tennessee Titans | Home | 33 - 19 | Final | Open |
| W3 | SEP 21, 2025 |  Indianapolis ColtsIndianapolis Colts @ Tennessee Titans | Home | 41 - 20 | Final | Open |
| W4 | SEP 28, 2025 |  Houston TexansTennessee Titans @ Houston Texans | Away | 0 - 26 | Final | Open |
| W5 | OCT 5, 2025 |  Arizona CardinalsTennessee Titans @ Arizona Cardinals | Away | 22 - 21 | Final | Open |
| W6 | OCT 12, 2025 |  Las Vegas RaidersTennessee Titans @ Las Vegas Raiders | Away | 10 - 20 | Final | Open |
| W7 | OCT 19, 2025 |  New England PatriotsNew England Patriots @ Tennessee Titans | Home | 31 - 13 | Final | Open |
| W8 | OCT 26, 2025 | Indianapolis ColtsTennessee Titans @ Indianapolis Colts | Away | 14 - 38 | Final | Open |
| W9 | NOV 2, 2025 |  Los Angeles ChargersLos Angeles Chargers @ Tennessee Titans | Home | 27 - 20 | Final | Open |
| W10 | - | ByeTennessee Titans Bye Week | - | - | Bye | Rest |
| W11 | NOV 16, 2025 | Houston TexansHouston Texans @ Tennessee Titans | Home | 16 - 13 | Final | Open |
| W12 | NOV 23, 2025 |  Seattle SeahawksSeattle Seahawks @ Tennessee Titans | Home | 30 - 24 | Final | Open |
| W13 | NOV 30, 2025 |  Jacksonville JaguarsJacksonville Jaguars @ Tennessee Titans | Home | 25 - 3 | Final | Open |
| W14 | DEC 7, 2025 |  Cleveland BrownsTennessee Titans @ Cleveland Browns | Away | 31 - 29 | Final | Open |
| W15 | DEC 14, 2025 |  San Francisco 49ersTennessee Titans @ San Francisco 49ers | Away | 24 - 37 | Final | Open |
| W16 | DEC 21, 2025 |  Kansas City ChiefsKansas City Chiefs @ Tennessee Titans | Home | 9 - 26 | Final | Open |
| W17 | DEC 28, 2025 |  New Orleans SaintsNew Orleans Saints @ Tennessee Titans | Home | 34 - 26 | Final | Open |
| W18 | JAN 4, 2026 | Jacksonville JaguarsTennessee Titans @ Jacksonville Jaguars | Away | 7 - 41 | Final | Open |
