| W1 | SEP 7, 2025 |  Atlanta FalconsTampa Bay Buccaneers @ Atlanta Falcons | Away | 23 - 20 | Final | Open |
| W2 | SEP 15, 2025 |  Houston TexansTampa Bay Buccaneers @ Houston Texans | Away | 20 - 19 | Final | Open |
| W3 | SEP 21, 2025 |  New York JetsNew York Jets @ Tampa Bay Buccaneers | Home | 27 - 29 | Final | Open |
| W4 | SEP 28, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Tampa Bay Buccaneers | Home | 31 - 25 | Final | Open |
| W5 | OCT 5, 2025 |  Seattle SeahawksTampa Bay Buccaneers @ Seattle Seahawks | Away | 38 - 35 | Final | Open |
| W6 | OCT 12, 2025 |  San Francisco 49ersSan Francisco 49ers @ Tampa Bay Buccaneers | Home | 19 - 30 | Final | Open |
| W7 | OCT 20, 2025 |  Detroit LionsTampa Bay Buccaneers @ Detroit Lions | Away | 9 - 24 | Final | Open |
| W8 | OCT 26, 2025 |  New Orleans SaintsTampa Bay Buccaneers @ New Orleans Saints | Away | 23 - 3 | Final | Open |
| W9 | - | ByeTampa Bay Buccaneers Bye Week | - | - | Bye | Rest |
| W10 | NOV 9, 2025 |  New England PatriotsNew England Patriots @ Tampa Bay Buccaneers | Home | 28 - 23 | Final | Open |
| W11 | NOV 16, 2025 |  Buffalo BillsTampa Bay Buccaneers @ Buffalo Bills | Away | 32 - 44 | Final | Open |
| W12 | NOV 23, 2025 |  Los Angeles RamsTampa Bay Buccaneers @ Los Angeles Rams | Away | 7 - 34 | Final | Open |
| W13 | NOV 30, 2025 |  Arizona CardinalsArizona Cardinals @ Tampa Bay Buccaneers | Home | 17 - 20 | Final | Open |
| W14 | DEC 7, 2025 | New Orleans SaintsNew Orleans Saints @ Tampa Bay Buccaneers | Home | 24 - 20 | Final | Open |
| W15 | DEC 11, 2025 | Atlanta FalconsAtlanta Falcons @ Tampa Bay Buccaneers | Home | 29 - 28 | Final | Open |
| W16 | DEC 21, 2025 |  Carolina PanthersTampa Bay Buccaneers @ Carolina Panthers | Away | 20 - 23 | Final | Open |
| W17 | DEC 28, 2025 |  Miami DolphinsTampa Bay Buccaneers @ Miami Dolphins | Away | 17 - 20 | Final | Open |
| W18 | JAN 3, 2026 | Carolina PanthersCarolina Panthers @ Tampa Bay Buccaneers | Home | 14 - 16 | Final | Open |
