| W1 | SEP 7, 2025 |  San Francisco 49ersSan Francisco 49ers @ Seattle Seahawks | Home | 17 - 13 | Final | Open |
| W2 | SEP 14, 2025 |  Pittsburgh SteelersSeattle Seahawks @ Pittsburgh Steelers | Away | 31 - 17 | Final | Open |
| W3 | SEP 21, 2025 |  New Orleans SaintsNew Orleans Saints @ Seattle Seahawks | Home | 13 - 44 | Final | Open |
| W4 | SEP 25, 2025 |  Arizona CardinalsSeattle Seahawks @ Arizona Cardinals | Away | 23 - 20 | Final | Open |
| W5 | OCT 5, 2025 |  Tampa Bay BuccaneersTampa Bay Buccaneers @ Seattle Seahawks | Home | 38 - 35 | Final | Open |
| W6 | OCT 12, 2025 |  Jacksonville JaguarsSeattle Seahawks @ Jacksonville Jaguars | Away | 20 - 12 | Final | Open |
| W7 | OCT 20, 2025 |  Houston TexansHouston Texans @ Seattle Seahawks | Home | 19 - 27 | Final | Open |
| W8 | - | ByeSeattle Seahawks Bye Week | - | - | Bye | Rest |
| W9 | NOV 2, 2025 |  Washington CommandersSeattle Seahawks @ Washington Commanders | Away | 38 - 14 | Final | Open |
| W10 | NOV 9, 2025 | Arizona CardinalsArizona Cardinals @ Seattle Seahawks | Home | 22 - 44 | Final | Open |
| W11 | NOV 16, 2025 |  Los Angeles RamsSeattle Seahawks @ Los Angeles Rams | Away | 19 - 21 | Final | Open |
| W12 | NOV 23, 2025 |  Tennessee TitansSeattle Seahawks @ Tennessee Titans | Away | 30 - 24 | Final | Open |
| W13 | NOV 30, 2025 |  Minnesota VikingsMinnesota Vikings @ Seattle Seahawks | Home | 0 - 26 | Final | Open |
| W14 | DEC 7, 2025 |  Atlanta FalconsSeattle Seahawks @ Atlanta Falcons | Away | 37 - 9 | Final | Open |
| W15 | DEC 14, 2025 |  Indianapolis ColtsIndianapolis Colts @ Seattle Seahawks | Home | 16 - 18 | Final | Open |
| W16 | DEC 18, 2025 | Los Angeles RamsLos Angeles Rams @ Seattle Seahawks | Home | 37 - 38 | Final | Open |
| W17 | DEC 28, 2025 |  Carolina PanthersSeattle Seahawks @ Carolina Panthers | Away | 27 - 10 | Final | Open |
| W18 | JAN 3, 2026 | San Francisco 49ersSeattle Seahawks @ San Francisco 49ers | Away | 13 - 3 | Final | Open |
