| W1 | SEP 7, 2025 |  New York JetsPittsburgh Steelers @ New York Jets | Away | 34 - 32 | Final | Open |
| W2 | SEP 14, 2025 |  Seattle SeahawksSeattle Seahawks @ Pittsburgh Steelers | Home | 31 - 17 | Final | Open |
| W3 | SEP 21, 2025 |  New England PatriotsPittsburgh Steelers @ New England Patriots | Away | 21 - 14 | Final | Open |
| W4 | SEP 28, 2025 |  Minnesota VikingsMinnesota Vikings @ Pittsburgh Steelers | Home | 21 - 24 | Final | Open |
| W5 | - | ByePittsburgh Steelers Bye Week | - | - | Bye | Rest |
| W6 | OCT 12, 2025 |  Cleveland BrownsCleveland Browns @ Pittsburgh Steelers | Home | 9 - 23 | Final | Open |
| W7 | OCT 16, 2025 |  Cincinnati BengalsPittsburgh Steelers @ Cincinnati Bengals | Away | 31 - 33 | Final | Open |
| W8 | OCT 26, 2025 |  Green Bay PackersGreen Bay Packers @ Pittsburgh Steelers | Home | 35 - 25 | Final | Open |
| W9 | NOV 2, 2025 |  Indianapolis ColtsIndianapolis Colts @ Pittsburgh Steelers | Home | 20 - 27 | Final | Open |
| W10 | NOV 9, 2025 |  Los Angeles ChargersPittsburgh Steelers @ Los Angeles Chargers | Away | 10 - 25 | Final | Open |
| W11 | NOV 16, 2025 | Cincinnati BengalsCincinnati Bengals @ Pittsburgh Steelers | Home | 12 - 34 | Final | Open |
| W12 | NOV 23, 2025 |  Chicago BearsPittsburgh Steelers @ Chicago Bears | Away | 28 - 31 | Final | Open |
| W13 | NOV 30, 2025 |  Buffalo BillsBuffalo Bills @ Pittsburgh Steelers | Home | 26 - 7 | Final | Open |
| W14 | DEC 7, 2025 |  Baltimore RavensPittsburgh Steelers @ Baltimore Ravens | Away | 27 - 22 | Final | Open |
| W15 | DEC 15, 2025 |  Miami DolphinsMiami Dolphins @ Pittsburgh Steelers | Home | 15 - 28 | Final | Open |
| W16 | DEC 21, 2025 |  Detroit LionsPittsburgh Steelers @ Detroit Lions | Away | 29 - 24 | Final | Open |
| W17 | DEC 28, 2025 | Cleveland BrownsPittsburgh Steelers @ Cleveland Browns | Away | 6 - 13 | Final | Open |
| W18 | JAN 4, 2026 | Baltimore RavensBaltimore Ravens @ Pittsburgh Steelers | Home | 24 - 26 | Final | Open |
