| W1 | SEP 4, 2025 | Dallas CowboysDallas Cowboys @ Philadelphia Eagles | Home | 20 - 24 | Final | Open |
| W2 | SEP 14, 2025 | Kansas City ChiefsPhiladelphia Eagles @ Kansas City Chiefs | Away | 20 - 17 | Final | Open |
| W3 | SEP 21, 2025 | Los Angeles RamsLos Angeles Rams @ Philadelphia Eagles | Home | 26 - 33 | Final | Open |
| W4 | SEP 28, 2025 | Tampa Bay BuccaneersPhiladelphia Eagles @ Tampa Bay Buccaneers | Away | 31 - 25 | Final | Open |
| W5 | OCT 5, 2025 | Denver BroncosDenver Broncos @ Philadelphia Eagles | Home | 21 - 17 | Final | Open |
| W6 | OCT 9, 2025 | New York GiantsPhiladelphia Eagles @ New York Giants | Away | 17 - 34 | Final | Open |
| W7 | OCT 19, 2025 | Minnesota VikingsPhiladelphia Eagles @ Minnesota Vikings | Away | 28 - 22 | Final | Open |
| W8 | OCT 26, 2025 | New York GiantsNew York Giants @ Philadelphia Eagles | Home | 20 - 38 | Final | Open |
| W9 | - | ByePhiladelphia Eagles Bye Week | - | - | Bye | Rest |
| W10 | NOV 10, 2025 | Green Bay PackersPhiladelphia Eagles @ Green Bay Packers | Away | 10 - 7 | Final | Open |
| W11 | NOV 16, 2025 | Detroit LionsDetroit Lions @ Philadelphia Eagles | Home | 9 - 16 | Final | Open |
| W12 | NOV 23, 2025 | Dallas CowboysPhiladelphia Eagles @ Dallas Cowboys | Away | 21 - 24 | Final | Open |
| W13 | NOV 28, 2025 | Chicago BearsChicago Bears @ Philadelphia Eagles | Home | 24 - 15 | Final | Open |
| W14 | DEC 8, 2025 | Los Angeles ChargersPhiladelphia Eagles @ Los Angeles Chargers | Away | 19 - 22 | Final | Open |
| W15 | DEC 14, 2025 | Las Vegas RaidersLas Vegas Raiders @ Philadelphia Eagles | Home | 0 - 31 | Final | Open |
| W16 | DEC 20, 2025 | Washington CommandersPhiladelphia Eagles @ Washington Commanders | Away | 29 - 18 | Final | Open |
| W17 | DEC 28, 2025 | Buffalo BillsPhiladelphia Eagles @ Buffalo Bills | Away | 13 - 12 | Final | Open |
| W18 | JAN 4, 2026 | Washington CommandersWashington Commanders @ Philadelphia Eagles | Home | 24 - 17 | Final | Open |