| W1 | SEP 7, 2025 |  Washington CommandersNew York Giants @ Washington Commanders | Away | 6 - 21 | Final | Open |
| W2 | SEP 14, 2025 |  Dallas CowboysNew York Giants @ Dallas Cowboys | Away | 37 - 40 | Final | Open |
| W3 | SEP 21, 2025 |  Kansas City ChiefsKansas City Chiefs @ New York Giants | Home | 22 - 9 | Final | Open |
| W4 | SEP 28, 2025 |  Los Angeles ChargersLos Angeles Chargers @ New York Giants | Home | 18 - 21 | Final | Open |
| W5 | OCT 5, 2025 |  New Orleans SaintsNew York Giants @ New Orleans Saints | Away | 14 - 26 | Final | Open |
| W6 | OCT 9, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ New York Giants | Home | 17 - 34 | Final | Open |
| W7 | OCT 19, 2025 |  Denver BroncosNew York Giants @ Denver Broncos | Away | 32 - 33 | Final | Open |
| W8 | OCT 26, 2025 | Philadelphia EaglesNew York Giants @ Philadelphia Eagles | Away | 20 - 38 | Final | Open |
| W9 | NOV 2, 2025 |  San Francisco 49ersSan Francisco 49ers @ New York Giants | Home | 34 - 24 | Final | Open |
| W10 | NOV 9, 2025 |  Chicago BearsNew York Giants @ Chicago Bears | Away | 20 - 24 | Final | Open |
| W11 | NOV 16, 2025 |  Green Bay PackersGreen Bay Packers @ New York Giants | Home | 27 - 20 | Final | Open |
| W12 | NOV 23, 2025 |  Detroit LionsNew York Giants @ Detroit Lions | Away | 27 - 34 | Final | Open |
| W13 | DEC 1, 2025 |  New England PatriotsNew York Giants @ New England Patriots | Away | 15 - 33 | Final | Open |
| W14 | - | ByeNew York Giants Bye Week | - | - | Bye | Rest |
| W15 | DEC 14, 2025 | Washington CommandersWashington Commanders @ New York Giants | Home | 29 - 21 | Final | Open |
| W16 | DEC 21, 2025 |  Minnesota VikingsMinnesota Vikings @ New York Giants | Home | 16 - 13 | Final | Open |
| W17 | DEC 28, 2025 |  Las Vegas RaidersNew York Giants @ Las Vegas Raiders | Away | 34 - 10 | Final | Open |
| W18 | JAN 4, 2026 | Dallas CowboysDallas Cowboys @ New York Giants | Home | 17 - 34 | Final | Open |
