| W1 | SEP 7, 2025 |  Arizona CardinalsArizona Cardinals @ New Orleans Saints | Home | 20 - 13 | Final | Open |
| W2 | SEP 14, 2025 |  San Francisco 49ersSan Francisco 49ers @ New Orleans Saints | Home | 26 - 21 | Final | Open |
| W3 | SEP 21, 2025 |  Seattle SeahawksNew Orleans Saints @ Seattle Seahawks | Away | 13 - 44 | Final | Open |
| W4 | SEP 28, 2025 |  Buffalo BillsNew Orleans Saints @ Buffalo Bills | Away | 19 - 31 | Final | Open |
| W5 | OCT 5, 2025 |  New York GiantsNew York Giants @ New Orleans Saints | Home | 14 - 26 | Final | Open |
| W6 | OCT 12, 2025 |  New England PatriotsNew England Patriots @ New Orleans Saints | Home | 25 - 19 | Final | Open |
| W7 | OCT 19, 2025 |  Chicago BearsNew Orleans Saints @ Chicago Bears | Away | 14 - 26 | Final | Open |
| W8 | OCT 26, 2025 |  Tampa Bay BuccaneersTampa Bay Buccaneers @ New Orleans Saints | Home | 23 - 3 | Final | Open |
| W9 | NOV 2, 2025 |  Los Angeles RamsNew Orleans Saints @ Los Angeles Rams | Away | 10 - 34 | Final | Open |
| W10 | NOV 9, 2025 |  Carolina PanthersNew Orleans Saints @ Carolina Panthers | Away | 17 - 7 | Final | Open |
| W11 | - | ByeNew Orleans Saints Bye Week | - | - | Bye | Rest |
| W12 | NOV 23, 2025 |  Atlanta FalconsAtlanta Falcons @ New Orleans Saints | Home | 24 - 10 | Final | Open |
| W13 | NOV 30, 2025 |  Miami DolphinsNew Orleans Saints @ Miami Dolphins | Away | 17 - 21 | Final | Open |
| W14 | DEC 7, 2025 | Tampa Bay BuccaneersNew Orleans Saints @ Tampa Bay Buccaneers | Away | 24 - 20 | Final | Open |
| W15 | DEC 14, 2025 | Carolina PanthersCarolina Panthers @ New Orleans Saints | Home | 17 - 20 | Final | Open |
| W16 | DEC 21, 2025 |  New York JetsNew York Jets @ New Orleans Saints | Home | 6 - 29 | Final | Open |
| W17 | DEC 28, 2025 |  Tennessee TitansNew Orleans Saints @ Tennessee Titans | Away | 34 - 26 | Final | Open |
| W18 | JAN 4, 2026 | Atlanta FalconsNew Orleans Saints @ Atlanta Falcons | Away | 17 - 19 | Final | Open |
