| W1 | SEP 7, 2025 |  Las Vegas RaidersLas Vegas Raiders @ New England Patriots | Home | 20 - 13 | Final | Open |
| W2 | SEP 14, 2025 |  Miami DolphinsNew England Patriots @ Miami Dolphins | Away | 33 - 27 | Final | Open |
| W3 | SEP 21, 2025 |  Pittsburgh SteelersPittsburgh Steelers @ New England Patriots | Home | 21 - 14 | Final | Open |
| W4 | SEP 28, 2025 |  Carolina PanthersCarolina Panthers @ New England Patriots | Home | 13 - 42 | Final | Open |
| W5 | OCT 5, 2025 |  Buffalo BillsNew England Patriots @ Buffalo Bills | Away | 23 - 20 | Final | Open |
| W6 | OCT 12, 2025 |  New Orleans SaintsNew England Patriots @ New Orleans Saints | Away | 25 - 19 | Final | Open |
| W7 | OCT 19, 2025 |  Tennessee TitansNew England Patriots @ Tennessee Titans | Away | 31 - 13 | Final | Open |
| W8 | OCT 26, 2025 |  Cleveland BrownsCleveland Browns @ New England Patriots | Home | 13 - 32 | Final | Open |
| W9 | NOV 2, 2025 |  Atlanta FalconsAtlanta Falcons @ New England Patriots | Home | 23 - 24 | Final | Open |
| W10 | NOV 9, 2025 |  Tampa Bay BuccaneersNew England Patriots @ Tampa Bay Buccaneers | Away | 28 - 23 | Final | Open |
| W11 | NOV 13, 2025 |  New York JetsNew York Jets @ New England Patriots | Home | 14 - 27 | Final | Open |
| W12 | NOV 23, 2025 |  Cincinnati BengalsNew England Patriots @ Cincinnati Bengals | Away | 26 - 20 | Final | Open |
| W13 | DEC 1, 2025 |  New York GiantsNew York Giants @ New England Patriots | Home | 15 - 33 | Final | Open |
| W14 | - | ByeNew England Patriots Bye Week | - | - | Bye | Rest |
| W15 | DEC 14, 2025 | Buffalo BillsBuffalo Bills @ New England Patriots | Home | 35 - 31 | Final | Open |
| W16 | DEC 21, 2025 |  Baltimore RavensNew England Patriots @ Baltimore Ravens | Away | 28 - 24 | Final | Open |
| W17 | DEC 28, 2025 | New York JetsNew England Patriots @ New York Jets | Away | 42 - 10 | Final | Open |
| W18 | JAN 4, 2026 | Miami DolphinsMiami Dolphins @ New England Patriots | Home | 10 - 38 | Final | Open |
