| W1 | SEP 8, 2025 |  Chicago BearsMinnesota Vikings @ Chicago Bears | Away | 27 - 24 | Final | Open |
| W2 | SEP 14, 2025 |  Atlanta FalconsAtlanta Falcons @ Minnesota Vikings | Home | 22 - 6 | Final | Open |
| W3 | SEP 21, 2025 |  Cincinnati BengalsCincinnati Bengals @ Minnesota Vikings | Home | 10 - 48 | Final | Open |
| W4 | SEP 28, 2025 |  Pittsburgh SteelersMinnesota Vikings @ Pittsburgh Steelers | Away | 21 - 24 | Final | Open |
| W5 | OCT 5, 2025 |  Cleveland BrownsMinnesota Vikings @ Cleveland Browns | Away | 21 - 17 | Final | Open |
| W6 | - | ByeMinnesota Vikings Bye Week | - | - | Bye | Rest |
| W7 | OCT 19, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Minnesota Vikings | Home | 28 - 22 | Final | Open |
| W8 | OCT 23, 2025 |  Los Angeles ChargersMinnesota Vikings @ Los Angeles Chargers | Away | 10 - 37 | Final | Open |
| W9 | NOV 2, 2025 |  Detroit LionsMinnesota Vikings @ Detroit Lions | Away | 27 - 24 | Final | Open |
| W10 | NOV 9, 2025 |  Baltimore RavensBaltimore Ravens @ Minnesota Vikings | Home | 27 - 19 | Final | Open |
| W11 | NOV 16, 2025 | Chicago BearsChicago Bears @ Minnesota Vikings | Home | 19 - 17 | Final | Open |
| W12 | NOV 23, 2025 |  Green Bay PackersMinnesota Vikings @ Green Bay Packers | Away | 6 - 23 | Final | Open |
| W13 | NOV 30, 2025 |  Seattle SeahawksMinnesota Vikings @ Seattle Seahawks | Away | 0 - 26 | Final | Open |
| W14 | DEC 7, 2025 |  Washington CommandersWashington Commanders @ Minnesota Vikings | Home | 0 - 31 | Final | Open |
| W15 | DEC 14, 2025 |  Dallas CowboysMinnesota Vikings @ Dallas Cowboys | Away | 34 - 26 | Final | Open |
| W16 | DEC 21, 2025 |  New York GiantsMinnesota Vikings @ New York Giants | Away | 16 - 13 | Final | Open |
| W17 | DEC 25, 2025 | Detroit LionsDetroit Lions @ Minnesota Vikings | Home | 10 - 23 | Final | Open |
| W18 | JAN 4, 2026 | Green Bay PackersGreen Bay Packers @ Minnesota Vikings | Home | 3 - 16 | Final | Open |
