| W1 | SEP 7, 2025 |  Houston TexansHouston Texans @ Los Angeles Rams | Home | 9 - 14 | Final | Open |
| W2 | SEP 14, 2025 |  Tennessee TitansLos Angeles Rams @ Tennessee Titans | Away | 33 - 19 | Final | Open |
| W3 | SEP 21, 2025 |  Philadelphia EaglesLos Angeles Rams @ Philadelphia Eagles | Away | 26 - 33 | Final | Open |
| W4 | SEP 28, 2025 |  Indianapolis ColtsIndianapolis Colts @ Los Angeles Rams | Home | 20 - 27 | Final | Open |
| W5 | OCT 2, 2025 |  San Francisco 49ersSan Francisco 49ers @ Los Angeles Rams | Home | 26 - 23 | Final | Open |
| W6 | OCT 12, 2025 |  Baltimore RavensLos Angeles Rams @ Baltimore Ravens | Away | 17 - 3 | Final | Open |
| W7 | OCT 19, 2025 |  Jacksonville JaguarsLos Angeles Rams @ Jacksonville Jaguars | Away | 35 - 7 | Final | Open |
| W8 | - | ByeLos Angeles Rams Bye Week | - | - | Bye | Rest |
| W9 | NOV 2, 2025 |  New Orleans SaintsNew Orleans Saints @ Los Angeles Rams | Home | 10 - 34 | Final | Open |
| W10 | NOV 9, 2025 | San Francisco 49ersLos Angeles Rams @ San Francisco 49ers | Away | 42 - 26 | Final | Open |
| W11 | NOV 16, 2025 |  Seattle SeahawksSeattle Seahawks @ Los Angeles Rams | Home | 19 - 21 | Final | Open |
| W12 | NOV 23, 2025 |  Tampa Bay BuccaneersTampa Bay Buccaneers @ Los Angeles Rams | Home | 7 - 34 | Final | Open |
| W13 | NOV 30, 2025 |  Carolina PanthersLos Angeles Rams @ Carolina Panthers | Away | 28 - 31 | Final | Open |
| W14 | DEC 7, 2025 |  Arizona CardinalsLos Angeles Rams @ Arizona Cardinals | Away | 45 - 17 | Final | Open |
| W15 | DEC 14, 2025 |  Detroit LionsDetroit Lions @ Los Angeles Rams | Home | 34 - 41 | Final | Open |
| W16 | DEC 18, 2025 | Seattle SeahawksLos Angeles Rams @ Seattle Seahawks | Away | 37 - 38 | Final | Open |
| W17 | DEC 29, 2025 |  Atlanta FalconsLos Angeles Rams @ Atlanta Falcons | Away | 24 - 27 | Final | Open |
| W18 | JAN 4, 2026 | Arizona CardinalsArizona Cardinals @ Los Angeles Rams | Home | 20 - 37 | Final | Open |
