| W1 | SEP 5, 2025 |  Kansas City ChiefsKansas City Chiefs @ Los Angeles Chargers | Home | 21 - 27 | Final | Open |
| W2 | SEP 15, 2025 |  Las Vegas RaidersLos Angeles Chargers @ Las Vegas Raiders | Away | 20 - 9 | Final | Open |
| W3 | SEP 21, 2025 |  Denver BroncosDenver Broncos @ Los Angeles Chargers | Home | 20 - 23 | Final | Open |
| W4 | SEP 28, 2025 |  New York GiantsLos Angeles Chargers @ New York Giants | Away | 18 - 21 | Final | Open |
| W5 | OCT 5, 2025 |  Washington CommandersWashington Commanders @ Los Angeles Chargers | Home | 27 - 10 | Final | Open |
| W6 | OCT 12, 2025 |  Miami DolphinsLos Angeles Chargers @ Miami Dolphins | Away | 29 - 27 | Final | Open |
| W7 | OCT 19, 2025 |  Indianapolis ColtsIndianapolis Colts @ Los Angeles Chargers | Home | 38 - 24 | Final | Open |
| W8 | OCT 23, 2025 |  Minnesota VikingsMinnesota Vikings @ Los Angeles Chargers | Home | 10 - 37 | Final | Open |
| W9 | NOV 2, 2025 |  Tennessee TitansLos Angeles Chargers @ Tennessee Titans | Away | 27 - 20 | Final | Open |
| W10 | NOV 9, 2025 |  Pittsburgh SteelersPittsburgh Steelers @ Los Angeles Chargers | Home | 10 - 25 | Final | Open |
| W11 | NOV 16, 2025 |  Jacksonville JaguarsLos Angeles Chargers @ Jacksonville Jaguars | Away | 6 - 35 | Final | Open |
| W12 | - | ByeLos Angeles Chargers Bye Week | - | - | Bye | Rest |
| W13 | NOV 30, 2025 | Las Vegas RaidersLas Vegas Raiders @ Los Angeles Chargers | Home | 14 - 31 | Final | Open |
| W14 | DEC 8, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Los Angeles Chargers | Home | 19 - 22 | Final | Open |
| W15 | DEC 14, 2025 | Kansas City ChiefsLos Angeles Chargers @ Kansas City Chiefs | Away | 16 - 13 | Final | Open |
| W16 | DEC 21, 2025 |  Dallas CowboysLos Angeles Chargers @ Dallas Cowboys | Away | 34 - 17 | Final | Open |
| W17 | DEC 27, 2025 |  Houston TexansHouston Texans @ Los Angeles Chargers | Home | 20 - 16 | Final | Open |
| W18 | JAN 4, 2026 | Denver BroncosLos Angeles Chargers @ Denver Broncos | Away | 3 - 19 | Final | Open |
