| W1 | SEP 5, 2025 |  Los Angeles ChargersKansas City Chiefs @ Los Angeles Chargers | Away | 21 - 27 | Final | Open |
| W2 | SEP 14, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Kansas City Chiefs | Home | 20 - 17 | Final | Open |
| W3 | SEP 21, 2025 |  New York GiantsKansas City Chiefs @ New York Giants | Away | 22 - 9 | Final | Open |
| W4 | SEP 28, 2025 |  Baltimore RavensBaltimore Ravens @ Kansas City Chiefs | Home | 20 - 37 | Final | Open |
| W5 | OCT 6, 2025 |  Jacksonville JaguarsKansas City Chiefs @ Jacksonville Jaguars | Away | 28 - 31 | Final | Open |
| W6 | OCT 12, 2025 |  Detroit LionsDetroit Lions @ Kansas City Chiefs | Home | 17 - 30 | Final | Open |
| W7 | OCT 19, 2025 |  Las Vegas RaidersLas Vegas Raiders @ Kansas City Chiefs | Home | 0 - 31 | Final | Open |
| W8 | OCT 27, 2025 |  Washington CommandersWashington Commanders @ Kansas City Chiefs | Home | 7 - 28 | Final | Open |
| W9 | NOV 2, 2025 |  Buffalo BillsKansas City Chiefs @ Buffalo Bills | Away | 21 - 28 | Final | Open |
| W10 | - | ByeKansas City Chiefs Bye Week | - | - | Bye | Rest |
| W11 | NOV 16, 2025 |  Denver BroncosKansas City Chiefs @ Denver Broncos | Away | 19 - 22 | Final | Open |
| W12 | NOV 23, 2025 |  Indianapolis ColtsIndianapolis Colts @ Kansas City Chiefs | Home | 20 - 23 | Final | Open |
| W13 | NOV 27, 2025 |  Dallas CowboysKansas City Chiefs @ Dallas Cowboys | Away | 28 - 31 | Final | Open |
| W14 | DEC 7, 2025 |  Houston TexansHouston Texans @ Kansas City Chiefs | Home | 20 - 10 | Final | Open |
| W15 | DEC 14, 2025 | Los Angeles ChargersLos Angeles Chargers @ Kansas City Chiefs | Home | 16 - 13 | Final | Open |
| W16 | DEC 21, 2025 |  Tennessee TitansKansas City Chiefs @ Tennessee Titans | Away | 9 - 26 | Final | Open |
| W17 | DEC 25, 2025 | Denver BroncosDenver Broncos @ Kansas City Chiefs | Home | 20 - 13 | Final | Open |
| W18 | JAN 4, 2026 | Las Vegas RaidersKansas City Chiefs @ Las Vegas Raiders | Away | 12 - 14 | Final | Open |
