| W1 | SEP 7, 2025 |  Carolina PanthersCarolina Panthers @ Jacksonville Jaguars | Home | 10 - 26 | Final | Open |
| W2 | SEP 14, 2025 |  Cincinnati BengalsJacksonville Jaguars @ Cincinnati Bengals | Away | 27 - 31 | Final | Open |
| W3 | SEP 21, 2025 |  Houston TexansHouston Texans @ Jacksonville Jaguars | Home | 10 - 17 | Final | Open |
| W4 | SEP 28, 2025 |  San Francisco 49ersJacksonville Jaguars @ San Francisco 49ers | Away | 26 - 21 | Final | Open |
| W5 | OCT 6, 2025 |  Kansas City ChiefsKansas City Chiefs @ Jacksonville Jaguars | Home | 28 - 31 | Final | Open |
| W6 | OCT 12, 2025 |  Seattle SeahawksSeattle Seahawks @ Jacksonville Jaguars | Home | 20 - 12 | Final | Open |
| W7 | OCT 19, 2025 |  Los Angeles RamsLos Angeles Rams @ Jacksonville Jaguars | Home | 35 - 7 | Final | Open |
| W8 | - | ByeJacksonville Jaguars Bye Week | - | - | Bye | Rest |
| W9 | NOV 2, 2025 |  Las Vegas RaidersJacksonville Jaguars @ Las Vegas Raiders | Away | 30 - 29 | Final | Open |
| W10 | NOV 9, 2025 | Houston TexansJacksonville Jaguars @ Houston Texans | Away | 29 - 36 | Final | Open |
| W11 | NOV 16, 2025 |  Los Angeles ChargersLos Angeles Chargers @ Jacksonville Jaguars | Home | 6 - 35 | Final | Open |
| W12 | NOV 23, 2025 |  Arizona CardinalsJacksonville Jaguars @ Arizona Cardinals | Away | 27 - 24 | Final | Open |
| W13 | NOV 30, 2025 |  Tennessee TitansJacksonville Jaguars @ Tennessee Titans | Away | 25 - 3 | Final | Open |
| W14 | DEC 7, 2025 |  Indianapolis ColtsIndianapolis Colts @ Jacksonville Jaguars | Home | 19 - 36 | Final | Open |
| W15 | DEC 14, 2025 |  New York JetsNew York Jets @ Jacksonville Jaguars | Home | 20 - 48 | Final | Open |
| W16 | DEC 21, 2025 |  Denver BroncosJacksonville Jaguars @ Denver Broncos | Away | 34 - 20 | Final | Open |
| W17 | DEC 28, 2025 | Indianapolis ColtsJacksonville Jaguars @ Indianapolis Colts | Away | 23 - 17 | Final | Open |
| W18 | JAN 4, 2026 | Tennessee TitansTennessee Titans @ Jacksonville Jaguars | Home | 7 - 41 | Final | Open |
