| W1 | SEP 7, 2025 |  Los Angeles RamsHouston Texans @ Los Angeles Rams | Away | 9 - 14 | Final | Open |
| W2 | SEP 15, 2025 |  Tampa Bay BuccaneersTampa Bay Buccaneers @ Houston Texans | Home | 20 - 19 | Final | Open |
| W3 | SEP 21, 2025 |  Jacksonville JaguarsHouston Texans @ Jacksonville Jaguars | Away | 10 - 17 | Final | Open |
| W4 | SEP 28, 2025 |  Tennessee TitansTennessee Titans @ Houston Texans | Home | 0 - 26 | Final | Open |
| W5 | OCT 5, 2025 |  Baltimore RavensHouston Texans @ Baltimore Ravens | Away | 44 - 10 | Final | Open |
| W6 | - | ByeHouston Texans Bye Week | - | - | Bye | Rest |
| W7 | OCT 20, 2025 |  Seattle SeahawksHouston Texans @ Seattle Seahawks | Away | 19 - 27 | Final | Open |
| W8 | OCT 26, 2025 |  San Francisco 49ersSan Francisco 49ers @ Houston Texans | Home | 15 - 26 | Final | Open |
| W9 | NOV 2, 2025 |  Denver BroncosDenver Broncos @ Houston Texans | Home | 18 - 15 | Final | Open |
| W10 | NOV 9, 2025 | Jacksonville JaguarsJacksonville Jaguars @ Houston Texans | Home | 29 - 36 | Final | Open |
| W11 | NOV 16, 2025 | Tennessee TitansHouston Texans @ Tennessee Titans | Away | 16 - 13 | Final | Open |
| W12 | NOV 20, 2025 |  Buffalo BillsBuffalo Bills @ Houston Texans | Home | 19 - 23 | Final | Open |
| W13 | NOV 30, 2025 |  Indianapolis ColtsHouston Texans @ Indianapolis Colts | Away | 20 - 16 | Final | Open |
| W14 | DEC 7, 2025 |  Kansas City ChiefsHouston Texans @ Kansas City Chiefs | Away | 20 - 10 | Final | Open |
| W15 | DEC 14, 2025 |  Arizona CardinalsArizona Cardinals @ Houston Texans | Home | 20 - 40 | Final | Open |
| W16 | DEC 21, 2025 |  Las Vegas RaidersLas Vegas Raiders @ Houston Texans | Home | 21 - 23 | Final | Open |
| W17 | DEC 27, 2025 |  Los Angeles ChargersHouston Texans @ Los Angeles Chargers | Away | 20 - 16 | Final | Open |
| W18 | JAN 4, 2026 | Indianapolis ColtsIndianapolis Colts @ Houston Texans | Home | 30 - 38 | Final | Open |
