| W1 | SEP 7, 2025 |  Detroit LionsDetroit Lions @ Green Bay Packers | Home | 13 - 27 | Final | Open |
| W2 | SEP 11, 2025 |  Washington CommandersWashington Commanders @ Green Bay Packers | Home | 18 - 27 | Final | Open |
| W3 | SEP 21, 2025 |  Cleveland BrownsGreen Bay Packers @ Cleveland Browns | Away | 10 - 13 | Final | Open |
| W4 | SEP 28, 2025 |  Dallas CowboysGreen Bay Packers @ Dallas Cowboys | Away | 40 - 40 | Final | Open |
| W5 | - | ByeGreen Bay Packers Bye Week | - | - | Bye | Rest |
| W6 | OCT 12, 2025 |  Cincinnati BengalsCincinnati Bengals @ Green Bay Packers | Home | 18 - 27 | Final | Open |
| W7 | OCT 19, 2025 |  Arizona CardinalsGreen Bay Packers @ Arizona Cardinals | Away | 27 - 23 | Final | Open |
| W8 | OCT 26, 2025 |  Pittsburgh SteelersGreen Bay Packers @ Pittsburgh Steelers | Away | 35 - 25 | Final | Open |
| W9 | NOV 2, 2025 |  Carolina PanthersCarolina Panthers @ Green Bay Packers | Home | 16 - 13 | Final | Open |
| W10 | NOV 10, 2025 |  Philadelphia EaglesPhiladelphia Eagles @ Green Bay Packers | Home | 10 - 7 | Final | Open |
| W11 | NOV 16, 2025 |  New York GiantsGreen Bay Packers @ New York Giants | Away | 27 - 20 | Final | Open |
| W12 | NOV 23, 2025 |  Minnesota VikingsMinnesota Vikings @ Green Bay Packers | Home | 6 - 23 | Final | Open |
| W13 | NOV 27, 2025 | Detroit LionsGreen Bay Packers @ Detroit Lions | Away | 31 - 24 | Final | Open |
| W14 | DEC 7, 2025 |  Chicago BearsChicago Bears @ Green Bay Packers | Home | 21 - 28 | Final | Open |
| W15 | DEC 14, 2025 |  Denver BroncosGreen Bay Packers @ Denver Broncos | Away | 26 - 34 | Final | Open |
| W16 | DEC 20, 2025 | Chicago BearsGreen Bay Packers @ Chicago Bears | Away | 16 - 22 | Final | Open |
| W17 | DEC 27, 2025 |  Baltimore RavensBaltimore Ravens @ Green Bay Packers | Home | 41 - 24 | Final | Open |
| W18 | JAN 4, 2026 | Minnesota VikingsGreen Bay Packers @ Minnesota Vikings | Away | 3 - 16 | Final | Open |
