| W1 | SEP 7, 2025 |  Tennessee TitansTennessee Titans @ Denver Broncos | Home | 12 - 20 | Final | Open |
| W2 | SEP 14, 2025 |  Indianapolis ColtsDenver Broncos @ Indianapolis Colts | Away | 28 - 29 | Final | Open |
| W3 | SEP 21, 2025 |  Los Angeles ChargersDenver Broncos @ Los Angeles Chargers | Away | 20 - 23 | Final | Open |
| W4 | SEP 29, 2025 |  Cincinnati BengalsCincinnati Bengals @ Denver Broncos | Home | 3 - 28 | Final | Open |
| W5 | OCT 5, 2025 |  Philadelphia EaglesDenver Broncos @ Philadelphia Eagles | Away | 21 - 17 | Final | Open |
| W6 | OCT 12, 2025 |  New York JetsDenver Broncos @ New York Jets | Away | 13 - 11 | Final | Open |
| W7 | OCT 19, 2025 |  New York GiantsNew York Giants @ Denver Broncos | Home | 32 - 33 | Final | Open |
| W8 | OCT 26, 2025 |  Dallas CowboysDallas Cowboys @ Denver Broncos | Home | 24 - 44 | Final | Open |
| W9 | NOV 2, 2025 |  Houston TexansDenver Broncos @ Houston Texans | Away | 18 - 15 | Final | Open |
| W10 | NOV 6, 2025 |  Las Vegas RaidersLas Vegas Raiders @ Denver Broncos | Home | 7 - 10 | Final | Open |
| W11 | NOV 16, 2025 |  Kansas City ChiefsKansas City Chiefs @ Denver Broncos | Home | 19 - 22 | Final | Open |
| W12 | - | ByeDenver Broncos Bye Week | - | - | Bye | Rest |
| W13 | NOV 30, 2025 |  Washington CommandersDenver Broncos @ Washington Commanders | Away | 27 - 26 | Final | Open |
| W14 | DEC 7, 2025 | Las Vegas RaidersDenver Broncos @ Las Vegas Raiders | Away | 24 - 17 | Final | Open |
| W15 | DEC 14, 2025 |  Green Bay PackersGreen Bay Packers @ Denver Broncos | Home | 26 - 34 | Final | Open |
| W16 | DEC 21, 2025 |  Jacksonville JaguarsJacksonville Jaguars @ Denver Broncos | Home | 34 - 20 | Final | Open |
| W17 | DEC 25, 2025 | Kansas City ChiefsDenver Broncos @ Kansas City Chiefs | Away | 20 - 13 | Final | Open |
| W18 | JAN 4, 2026 | Los Angeles ChargersLos Angeles Chargers @ Denver Broncos | Home | 3 - 19 | Final | Open |
