| W1 | SEP 7, 2025 |  New Orleans SaintsArizona Cardinals @ New Orleans Saints | Away | 20 - 13 | Final | Open |
| W2 | SEP 14, 2025 |  Carolina PanthersCarolina Panthers @ Arizona Cardinals | Home | 22 - 27 | Final | Open |
| W3 | SEP 21, 2025 |  San Francisco 49ersArizona Cardinals @ San Francisco 49ers | Away | 15 - 16 | Final | Open |
| W4 | SEP 25, 2025 |  Seattle SeahawksSeattle Seahawks @ Arizona Cardinals | Home | 23 - 20 | Final | Open |
| W5 | OCT 5, 2025 |  Tennessee TitansTennessee Titans @ Arizona Cardinals | Home | 22 - 21 | Final | Open |
| W6 | OCT 12, 2025 |  Indianapolis ColtsArizona Cardinals @ Indianapolis Colts | Away | 27 - 31 | Final | Open |
| W7 | OCT 19, 2025 |  Green Bay PackersGreen Bay Packers @ Arizona Cardinals | Home | 27 - 23 | Final | Open |
| W8 | - | ByeArizona Cardinals Bye Week | - | - | Bye | Rest |
| W9 | NOV 3, 2025 |  Dallas CowboysArizona Cardinals @ Dallas Cowboys | Away | 27 - 17 | Final | Open |
| W10 | NOV 9, 2025 | Seattle SeahawksArizona Cardinals @ Seattle Seahawks | Away | 22 - 44 | Final | Open |
| W11 | NOV 16, 2025 | San Francisco 49ersSan Francisco 49ers @ Arizona Cardinals | Home | 41 - 22 | Final | Open |
| W12 | NOV 23, 2025 |  Jacksonville JaguarsJacksonville Jaguars @ Arizona Cardinals | Home | 27 - 24 | Final | Open |
| W13 | NOV 30, 2025 |  Tampa Bay BuccaneersArizona Cardinals @ Tampa Bay Buccaneers | Away | 17 - 20 | Final | Open |
| W14 | DEC 7, 2025 |  Los Angeles RamsLos Angeles Rams @ Arizona Cardinals | Home | 45 - 17 | Final | Open |
| W15 | DEC 14, 2025 |  Houston TexansArizona Cardinals @ Houston Texans | Away | 20 - 40 | Final | Open |
| W16 | DEC 21, 2025 |  Atlanta FalconsAtlanta Falcons @ Arizona Cardinals | Home | 26 - 19 | Final | Open |
| W17 | DEC 28, 2025 |  Cincinnati BengalsArizona Cardinals @ Cincinnati Bengals | Away | 14 - 37 | Final | Open |
| W18 | JAN 4, 2026 | Los Angeles RamsArizona Cardinals @ Los Angeles Rams | Away | 20 - 37 | Final | Open |
